High Total Protein in Blood: What Does It Mean and What to Do

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You’ve just gotten back blood test results, and something’s off. Your doctor says you have high protein levels. Well, what happens if my total protein in blood is high? It’s a surprisingly common concern, and this post is here to explain. Instead of panicking, let’s take a calm look at what it all means, why it happens, and what can be done about it.

First things first: It doesn’t necessarily mean you’re seriously sick. However, it’s an important signal from your body that something needs further investigation. Let’s demystify high protein in your blood together.

Table of Contents:

What is Total Protein in Blood?

Before we get to the “high” part, let’s break down what “total protein” actually represents in a blood test. Basically, it’s a measure of all the proteins floating around in your blood. A total protein test is often part of a comprehensive metabolic panel or ordered alongside a complete blood count.

Now, proteins aren’t inherently bad. In fact, they’re absolutely vital for almost every function your body carries out. Think of proteins as tiny workers that build and repair tissues, transport nutrients, and fight off infections. There are two main groups your test results usually focus on: albumin and globulin.

A normal total protein level typically falls between 6 to 8 grams per deciliter (g/dl) , but your doctor will determine what’s optimal for you. This measurement helps give your doctor a snapshot of your overall health.

Why Might My Total Protein Be High?

Alright, let’s get to what’s likely on your mind: What happens if my total protein in blood is high? There are several reasons for high total protein. The thing is, simply having a high protein diet doesn’t usually directly translate to high blood protein.

It’s usually a bit more complex than that, pointing towards something your body is doing internally. Your doctor will use your total protein test, alongside other tests, medical history, and physical examinations, to learn more about the cause of high protein levels.

Dehydration

Sometimes, the answer is simpler than you think. Dehydration is a common cause of high blood protein. This is a classic case of your blood becoming more concentrated because there isn’t enough water in it.

Think of making juice from concentrate; if you use less water, the flavor becomes much stronger. When your body is dehydrated, the fluid part of your blood decreases, making the concentration of proteins appear higher.

Infections and Inflammation

When you’re battling an infection, your body enters defense mode. This often means your immune system kicks into high gear, churning out more globulins, specifically immunoglobulins (antibodies), to fight it off. This can lead to high blood protein levels.

Chronic inflammation, where your body is basically in a constant state of alert, can have the same effect. Conditions like inflammatory bowel disease and rheumatoid arthritis can cause long-term inflammation and may lead to high total protein.

More Serious Conditions

Now, sometimes an elevated total protein level can be a sign of something more serious. These aren’t as common, but it’s important to rule them out. High blood protein levels warrant additional testing to help get to the root cause.

Some possibilities include liver disease, kidney disease, certain types of cancer (like multiple myeloma, Waldenstrom macroglobulinemia, and amyloidosis), or even autoimmune diseases. If dehydration and temporary inflammation are off the table, your doctor will likely order additional blood tests such as a comprehensive metabolic panel, to investigate.

What Happens Next?

Having high blood protein isn’t like having a cold where you just take some vitamin C and rest. It’s not a condition on its own but rather a clue to a potential underlying issue. If you’re experiencing symptoms of high blood protein, your provider may order a protein test.

Your doctor will use your total protein level alongside other symptoms, medical history, and further tests to get a complete picture. Once the cause is identified, the focus shifts to treating that, which in turn, usually takes care of the elevated protein levels.

High Protein in Urine?

While we’re talking protein, there’s a related topic worth mentioning: protein in your urine. Under normal circumstances, our bodies filter out waste products through the kidneys, but this filtration system is pretty awesome at keeping important stuff where it belongs.

Our kidneys only allow a small amount of protein to pass through into the urine, usually eliminating less than 150 milligrams (mg) of total protein daily via urine. Now, if your urine consistently contains more than 300mg of protein a day , that could be a red flag.

High protein in urine is called proteinuria, and it could be a sign of kidney problems. Conditions like preeclampsia in pregnant women can also manifest this way. Often, your doctor may order a 24-hour urine collection to get a better understanding.

Understanding Albumin and Globulin

Remember those two worker proteins we mentioned? They often hold crucial information for diagnoses when looking into elevated protein levels. In this section, we’ll discuss albumin protein and globulin in greater detail.

Albumin

Albumin is a powerhouse protein, and its levels are carefully regulated by your body. It’s made in the liver and acts like a tiny transporter, carrying hormones, vitamins, and medications around your system.

Albumin also plays a key role in maintaining the appropriate amount of fluid within your blood vessels and preventing it from leaking into other tissues. If your albumin is too low, it could be a sign of liver disease, kidney issues, or malnutrition.

On the flip side, high albumin levels could be linked to severe dehydration or prolonged diarrhea. When your doctor understands the levels of albumin, in conjunction with your total protein level, it helps them better understand your condition.

Globulin

Now, globulin is a team player, with various types existing, many made by your immune system. Think of them as your body’s defense squad against infections. Protein electrophoresis is a type of blood test that separates blood proteins, allowing your medical professionals to measure them.

If your globulin levels are abnormally high, your body might be battling an infection, inflammatory condition, or, in less common cases, it could be linked to autoimmune diseases or even some types of cancer. If your levels are low, your doctor may look into potential immune deficiencies or certain types of genetic disorders.

Taking Charge of Your Health

Let’s face it: seeing an abnormal blood test result can be a bit scary. The “What happens if my total protein in blood is high?” question likely brings about some anxieties. It’s important to take an active role in your health.

This natural response underscores the importance of regular checkups and open communication with your healthcare provider. Blood tests offer a window into your body’s inner workings, often revealing clues about your health even before noticeable symptoms surface.

Conclusion

So, what happens if my total protein in blood is high? It depends. Your blood plasma contains numerous proteins.

Often, high total protein just needs a simple lifestyle change to bring things back into a normal range, but other times, it’s our body giving us an early warning signal that needs prompt attention. The best action is always to talk to your doctor; they’re the ones who can properly interpret what those numbers really mean for your overall well-being.

author avatar
Jose Rossello, MD, PhD, MHCM
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